Dr. Suryakiran Navath, Ph.D., a distinguished figure in the field of Organic Chemistry, brings over 25 years of extensive research experience to the realm of scientific exploration. Currently serving as the Editor-in-Chief at Sciforce Publications, Dr. Navath's expertise spans various interdisciplinary areas, including synthetic organic chemistry, medicinal chemistry, information technologies, data science, and database applications.
Throughout his illustrious career, Dr. Navath has made significant contributions to the scientific community. As a Ph.D. holder in Organic Chemistry, he has demonstrated a keen passion for advancing knowledge and innovation. His research endeavors have not only delved into the intricacies of synthetic organic chemistry but also extended to crucial domains such as medicinal chemistry.
Dr. Navath holds the prestigious role of a referee and peer reviewer for reputable journals, including Chemical Communications, Organic and Biomolecular Chemistry, Green Chemistry, Tetrahedron Letters, Journal of Combinatorial Chemistry, European Journal of Organic Chemistry, European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, Bioorganic & Medicinal Chemistry, Current Medicinal Chemistry, Current Chemical Biology, Green Chemistry Letters and Reviews, and Beilstein Journal of Organic Chemistry.
In addition to his editorial responsibilities, Dr. Navath is an esteemed member of professional societies, including the American Chemical Society (mACS), Royal Society of Chemistry (mRSC), American Association of Pharmaceutical Scientist (mAAPS), and American Association for Cancer Research (mAACR).
Dr. Navath's commitment to the scientific community is further underscored by his prolific publication record, which boasts over 65 articles. His multidisciplinary approach and dedication to advancing scientific knowledge make him a valuable asset to both Sciforce Publications and the wider scientific community.
AWARDS/FELLOWSHIPS
NASA Research Grant USA 2008-2012
Arizona Cancer Center Research Fellowship USA 2012-2013
NIH Research Fellowship USA 2008-2012
RESEARCH EXPERTISE
Academic and Industrial research experience in various areas of medicinal/synthetic organic chemistry, peptides chemistry, Nucleosides, carbohydrate chemistry, bioorganic chemistry, and heterocyclic chemistry and development of new synthetic methodology.
Expertise in conjugate chemistry(PEG), synthesis of biomaterials and their screening for drug delivery applications
Developed and validated analytical (bioanalytical) methods for estimation of drugs and their metabolites for pharmacokinetics/pharmacodynamics (PK/PD) studies. Extracted drugs and metabolites from plasma and tissue and estimated using HPLC, LC-MS, GS-MS and drug purity/stability studies using various analytical methods.
Designed site specific delivery systems: Designed and in-vitro drug release study. Screening of polymer drug conjugates in-vitro efficacy using cell culture techniques.
Image guided intervention and biodistribution of PEG nanocarriers: synthesis, characterization and in-vivo evaluation
Experience in preparation of fluorophore tagged conjugates (FITC)
PEGylation of anticancer drugs: Synthesis of multicopy 19F imaging nanocarriers through suitable enzyme activated peptidic linkage and in-vitro release studies.
Expertise working within GLP compliance and sterilized condition
Recent Publications
1 Dilani Chathurika Dehigaspitiya, Suryakiran Navath Synthesis and bioactivity of MSH4 oligomers prepared by an A + B strategy Tetrahedron Lett2015,56,3060-3065
2 Gary V. Martinez, Suryakiran Navath, Kamini Sewda, Venkataramanarao Rao, Parastou Foroutan, Ramesh Alleti, Ali M. Ahad, Robert J. Gillies, David L. Morse, and Eugene A. Mash, Demonstration of a Sucrose-derived, GI-Specific Contrast Agent for Magnetic Resonance Imaging. Bioorganic Medicinal Chemistry Letters2013, 2013, 23, 2061-2064
3 Venkataramanarao Rao, Suryakiran Navath, Mohankumar Kottur, James R. McElhanon, Dominic V. McGrath An efficient reverse Diels–Alder approach for the synthesis of N-alkyl bismaleimides Tetrahedron Letters2013, 54, 5011–5013
4 S. Rajaram, K. Suresh Babu, U. Ramulu,D. Ramesh, D. Srikanth,Shasi V. Kalivendi, Papri Bhattacharya, P. Prabhakar, N. Suryakiran, Y. Venkateswarlu Isolation, semi-synthesis and bio-evaluation of furano-sesquiterpene carboxylic acids from the soft coral Sinularia kavarattiensis Bioorganic Medicinal Chemistry Letters2013, 23,6234-6238
5 Suryakiran Navath, Venkataramanarao Rao, Ramesh Alleti, Ali M. Ahad, Pawel Kiela and Eugene A. Mash. Design, Synthesis, and Testing of molecular Truck for colonic Delivery of 5-Aminosalicilic Acid ACS Medicinal Chemistry 2012, 3, 710–714
6 T. Srikanth Reddy, N. Suryakiran and Y. Venkateswarlu. Semi-synthesis and anti-bacterial evaluation of polybrominated diphenyl ethers. BioorganicMedicinal ChemistryLetters2012, 22, 4900-4906
7 N. Raghavendra Swamy, N. Suryakiran, P. Paradesi Naidu, Y. Venkateswarlu Synthesis of N-homobicyclic dideoxynucleoside analogues Carbohydrate Research 2012,352, 191-196
8 D. Ramesh, T. Srikanth Reddy, M. Narasimhulu, S. Rajaram, N. Suryakiran, K. Chinni Mahesh, Y. Venkateswarlu, Efficient and rapid stereoselective synthesis of trans-4,5- diaminocyclopent-2-enones by acidic ionic liquid under solvent-free conditions Chemistry Letters 2009, 38, 586-587.
9 J. Jon Paul Selvam, V. Suresh, K. Rajesh, D. Chanti Babu, N. Suryakiran, Y. Venkateswarlu A novel rapid sulfoxidation of sulfides with cyclohexylidenebishydroperoxide Tetrahedron Letters, 2008, 49, 346-3465.
10 N. Suryakiran, P. Prabhakar, T. Srikanth Reddy, K. Chinni Mahesh, K. Rajesh and Y. Venkateswarlu,Chemoselective mono halogenation of b-keto-sulfones using potassium halide and hydrogen peroxide; synthesis of halomethyl sulfones and dihalomethyl sulfones. Tetrahedron Letters2007, 48,877-881.
Research Publications to be communicated
1. Suryakiran Navath, Gary V. Martinez Kamini Sewda, Venkataramanarao Rao, Parastou Foroutan, Ramesh Alleti, Ali M. Ahad, Robert J. Gillies, David L. Morse, and Eugene A. Mash, Demonstration of a Sucrose-derived, GI-Specific Contrast Agent for Magnetic Resonance Imaging. Magnetic Resonance in Medicine (To be communicated)
2. Suryakiran Navath, Venkataramanarao Rao, Ramesh Alleti, Ali M. Ahad, Pawel Kiela and Eugene A. Mash. Design, Synthesis, and Testing of molecular Truck for colonic Delivery of 5-Aminosalicilic Acid Medicinal Chemistry (To be communicated)
3. Ramesh Alleti, Suryakiran Navath, Eugene A. Mash. NBD Labeled MSH(4) & CCK(4) Multimers BioorganicMedicinal ChemistryLetters. (To be communicated).
4. ChathurikaDehigaspitia, Suryakiran Navath, Eugene A. Mash. Click Derived MSH(4) Oligomers BioorganicMedicinal ChemistryLetters. (To be communicated).
5. Elshan, Suryakiran Navath, Eugene A. Mash. Small Chain MSH(4) & CCK(4) Multimers. BioorganicMedicinal ChemistryLetters. (To be communicated).
6. N. Suryakiran, Y. Bruce Yu, Designed and synthesized highly fluorinated drug imaging agents as multifunctional delivery vehicles for cancer therapy Journal of Medicinal Chemistry(To be communicated).
7. N. Suryakiran, Eugene A. Mash, D. Mahadevan Synthesis of 4’-(9-Acridinenylamino)butane-sulfonanilide for the treatment and management of patients with Gastrointestinal Stromal Tumors such as tyrosine kinase inhibitor and kinase inhibitor to Aurora Kinase.Journal of Medicinal Chemistry (To be communicated).
8. N. Suryakiran, Eugene A. Mash Wondrak G. T. Synthesis of 5’-phospho-N6-furfuryladenosine for Redox Drug Discovery Targeting Human Skin CancerMelanomaRes.(To be communicated).